The first thing to be clear is that your diagnosis is definitely Parkinson’s disease. If the diagnosis is not correct taking medication is not correct. If it is Parkinson’s disease, reasonable medication will definitely be effective. In the case of Parkinson’s syndrome (note that it is a syndrome), medication will not be effective. You need to find an experienced neurologist and ask which diagnosis you have. (Or please refer to my article: How do Parkinson’s disease and Parkinson’s syndrome differ?) Zhang Yuqing, Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University Secondly, you need to find out which period the disease is in. There is no doubt that the most central drug for the treatment of Parkinson’s disease must be Medopa (or Xanax). However, for the initial treatment of patients with mild disease, adjuvant drugs can be used. For example, MAO-B inhibitors (selagiline or resagiline), amantadine, anticholinergics (benzhexol hydrochloride), or dopamine agonists (senflor). Adjuvant drugs alone are effective in early Parkinson’s disease, but not in the long term, and must be supplemented with core medications for significant results (for more information, please follow my article: Several Drugs for Parkinson’s Disease). Again, pay attention to the dose of medication used and the time to take it. The dose of medication, for example, is at least 1/4 capsule once, 3 times a day, and the time to take the medication should be one hour before a meal. Especially milk and high-protein foods affect drug absorption the most (for more details, please refer to my article: Nutritional Care for Parkinson’s Patients). As the disease progresses, the dose of the drug is gradually increased. For example, 1/4 capsule of Medopa is usually ineffective for patients in the middle or late stages of the disease, and the dose needs to be increased appropriately. One last tip: even the best drugs have their limitations and side effects. Take Methocarbamol as an example, it is not effective if there is already difficulty in striding and balance. The side effects are the unpredictable “on/off” phenomenon and “ochronosis” after taking high doses (see my article: Are there side effects of Parkinson’s disease medication? What are “on/off” and “ochronosis”?) . Of course, surgery (pacemaker) can be effective in eliminating the side effects of medications and improving motor function, but it is expensive and not all patients can afford it, nor is it reimbursed by health insurance like Americans. For patients who are not expected to undergo surgery, it is not advisable to be too aggressive in medication, otherwise it will be difficult to treat them without surgery after opening up the medication.