Red bumps and itchy thighs are considered to be allergic skin diseases, possibly eczema or contact dermatitis. If the symptoms are mild and the rash is not particularly large, it can be treated by topical medication only, such as topical application of glyburide lotion, which has an astringent and anti-itching effect. You can also apply topical hormonal creams, such as mometasone furoate cream or dinaide cream. If the rash is more generalized and itchy, it can be treated with oral medications such as loratadine or levocetirizine hydrochloride, or with oral anti-inflammatory glycopyrrolate tablets. Treatment should also be accompanied by attention to avoid scratching and irritation, and a diet that avoids spicy and stimulating foods.