It is not recommended to extract teeth for a short period of time after the HPV vaccine, and it should be noted that there should be an interval of about 1 month before extracting teeth after the HPV vaccine. The HPV vaccine includes Septavalent, Quadrivalent and Bivalent. They are mainly used to prevent diseases, lesions, infections, etc. caused by the respective HPV types they contain. Adverse reactions such as fatigue, headache, myalgia, fever, nausea and vomiting, and hives may occur after use. If a tooth is extracted at this time, it is not possible to determine whether the adverse reaction is caused by the vaccine or by the tooth extraction, and it is easy to confuse the doctor’s judgment. During tooth extraction, local anesthetics will be injected, which may interfere with the drug properties of the HPV vaccine. Therefore, teeth extraction is generally not allowed after HPV vaccination. HPV is contraindicated in people who have hypersensitivity reactions to the active ingredient of the vaccine or any of the excipient components. Those who have symptoms of hypersensitivity reaction after injection should not be revaccinated. It is recommended that patients who have just finished HPV vaccination go for an interval of about one month before tooth extraction to avoid affecting the effect of the vaccine or adverse reactions.