There are many reasons for getting up in the morning with swollen hands, and the common ones are heart failure, nephrotic syndrome, rheumatoid arthritis and so on. 1. heart failure: the heart pumping function is impaired, cardiac blood output can not meet the basic metabolic needs of the body tissues, mainly manifested as dyspnea, neck vascular congestion, get up in the morning can be swollen hands and other water and sodium retention phenomenon. 2. Nephrotic syndrome: a group of clinical syndromes with similar symptoms caused by different etiological factors, often manifested as large amount of proteinuria, high degree of edema, hyperlipidemia and hypoproteinemia. The initial stage of edema can be eyelid edema and hand swelling in the morning, and edema in the lower limbs and ankles in the evening. 3. Rheumatoid arthritis: it is an autoimmune disease, mainly characterized by erosive arthritis. If it involves the wrist, palm, fingers and other parts of the body, it can be manifested as prolonged morning stiffness, swelling, pain, etc., and in severe cases, it can lead to deformity of the joints. Swollen hands in the morning may have other causes such as cervical spondylosis, etc., it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment.