Entecavir is an antiviral drug, and you generally won’t get liver cancer from taking entecavir. Liver cancer is related to hepatitis virus infection, cirrhosis of the liver, and taking antiviral drugs generally have no relationship. Entecavir is a guanine nucleoside analog with inhibitory effect on hepatitis B virus polymerase, clinically it is mainly used for the treatment of chronic adult hepatitis B with active viral replication, persistent elevation of serum alanine aminotransferase, or active lesions in liver histology. When patients with chronic adult hepatitis B take entecavir, their disease is usually effectively controlled and the risk of developing hepatocellular carcinoma can be reduced. At present, it is believed that the development of hepatocellular carcinoma is related to hepatitis viruses, cirrhosis, and certain chemical carcinogens, etc. These factors can affect the damage and repair of liver cells, oncogenes, etc., which can promote the development of hepatocellular carcinoma, but it has nothing to do with the use of antiviral drugs. In the course of treatment with entecavir, even if the patient’s condition is effectively controlled, regular review is still needed to check liver function, hepatitis B virus DNA, alpha-fetoprotein and so on, to be alert to the emergence of hepatocellular carcinoma. Taking entecavir generally will not get liver cancer, but entecavir needs to be taken in strict accordance with the doctor’s prescription. In addition, patients with liver cancer should be detected, diagnosed and treated early for better treatment.