Small follicles may be caused by polycystic ovary syndrome, early onset ovarian insufficiency, hyperprolactinemia and other diseases, which need to be treated with medication and surgery. 1. Polycystic ovary syndrome: small follicles may be caused by polycystic ovary syndrome, patients need to take oral progesterone drugs, such as dextroprogesterone, medroxyprogesterone acetate, luteinizing hormone and so on. Or clomiphene, letrozole and other ovulation-inducing drugs. 2. Early-onset ovarian insufficiency: small follicles may also be caused by early-onset ovarian insufficiency, patients can take oral estrogenic drugs under the guidance of the doctor, such as estradiol valerate, estradiol, etc., or oral microparticulated progesterone pills, progesterone capsules and other progesterone drugs. 3. Hyperprolactinemia: small follicles are also considered to be caused by hyperprolactinemia, patients take oral dopamine agonists as prescribed by the doctor, such as bromocriptine mesylate, carbamazole, quinagolide. In some patients, if non-surgical treatment is ineffective, surgical removal of the tumor can be taken, thus improving the prognosis. There are many reasons for small follicles, so it is recommended that patients consult a doctor in time to clarify the cause of the disease and take targeted treatment.