The etiology and pathogenesis of unexplained childhood hepatitis are still under research, and the treatment is based on rest, nutritional support, liver preservation, and active prevention of liver failure. 1. Rest: avoid strenuous exercise, reduce physical exertion, and take proper bed rest when there is fatigue, poor appetite, jaundice and vomiting. 2. Nutritional support: children who can eat should be given high-carbohydrate, low-fat, high-quality protein diet and supplemented with multivitamins, and those who do not eat enough should be supplemented intravenously to ensure calorie intake. 3. Hepatoprotection: use hepatoprotective drugs as appropriate, ursodeoxycholic acid can be used for those with cholestasis, pay attention to keep the bowels clear, and lactulose can be used for those with constipation to reduce the absorption of toxic substances. 4. Active prevention of liver failure: active fluid resuscitation, treatment of hepatic encephalopathy and intracranial hypertension, liver replacement therapy, when internal medicine treatment is ineffective, choose liver transplantation if the condition permits. Unexplained childhood hepatitis disease may also have other causes, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment. The above medication should be used in accordance with the doctor’s prescription.