Physiologic jaundice will not subside for more than two weeks in full-term infants and four weeks in preterm infants. Neonatal jaundice is divided into physiologic jaundice and pathologic jaundice, caused by different reasons. Physiologic jaundice is due to the increase in red blood cells after birth, and the increased destruction of red blood cells causes elevated bilirubin. Children with physiologic jaundice are in good condition, eating milk well, responding well, showing only mild yellow staining of the skin and mucous membranes, no complications will occur, and the value of jaundice will not be more than 12.9mg/dL. Physiologic jaundice doesn’t need any special intervention, and most of them will subside on their own. Physiologic jaundice will not subside for more than two weeks in full-term infants and four weeks in preterm infants. Pathologic jaundice is more likely to have complications and requires prompt treatment.