Blisters are generally referred to as blisters, and blisters under the soles of the feet may be caused by physiological factors such as poorly fitted shoes and long hours of walking, as well as other causes such as ringworm of the feet, eczema, and hand, foot and mouth disease. 1. Physiological factors: If you walk for a long time in ill-fitting shoes, the soles of your feet are prone to friction with the shoes, which will make the soles of your feet congested and edematous, resulting in the appearance of blisters. 2. Tinea pedis: tinea pedis is caused by the infection of the soles of the feet by dermatophytes, the patient’s soles, metatarsals, lateral edges of the feet and other parts of the blisters will appear the size of the pinpoints of the depth of the blisters, and some patients will also be accompanied by localized itching, flaking and other manifestations. 3. Eczema: the etiology of eczema is not yet clear, and it is considered to be related to heredity, internal chronic infection lesions, and exposure to chemical substances. Patients will have papules, papules, small blisters, itching and other manifestations. If the patient has eczema on the soles of the feet, there will be small blisters. 4. Other: patients with hand, foot and mouth disease and contact dermatitis on the soles of the feet will also have the performance of blisters. It is recommended that patients with long blisters on the soles of the feet need to consult a doctor in a timely manner, if it is caused by physiological factors, do not need to be treated. If it is caused by disease, it needs to be treated under the guidance of a doctor.