There are no specific medications for migraine, and it is generally accepted that relatively specific medications for migraine include ergotamine-type preparations and treprostinil. The specific choice of drugs should take into account the degree of pain, accompanying symptoms, previous use of drugs and other comprehensive considerations. 1. Triptans: Triptans are 5-hydroxytryptamine receptor agonists, mainly used for moderate or severe migraine, including sumatriptan and naratriptan. Triptans are effective at any time during the headache period, but the earlier they are applied, the better the effect, but for safety reasons, they are not advocated to be applied during the aura period. 2. Ergotamine preparations: the main role of ergotamine is to directly contract the vascular smooth muscle, so that the dilation of arterial contraction, to restore the normal cerebral arterial vascular beat, resulting in headache relief. However, a small amount of ergotamine can lead to overdose headache, so it is not recommended for routine use. Migraine headache should be under the guidance of a neurologist to avoid blind use of drugs.