Hypertension is a complex disease. Some people say that hypertension is a cardiovascular disease that is related to the heart and has no relationship with other organs. In fact, hypertension is closely related to many systems and organs of the body. Today we will mainly talk about the relationship between hypertension and kidney disease. The relationship between the kidneys and hypertension: 1. The kidneys secrete renin, which is a protein hydrolase released by the parabolic cells of the glomerular apparatus (also called the parabolic complex). Renin is involved in the activation of the renin-angiotensin-aldosterone system in the body, and this system is involved in the regulation of blood pressure. 2. During hemorrhage, renin produces angiotensin I by shearing angiotensinogen synthesized by the liver, and angiotensin I is further sheared by angiotensin-converting enzyme (ACE) to angiotensin II, which efficiently constricts blood vessels, increases aldosterone and antidiuretic hormone secretion, and stimulates hypothalamus to produce thirst. It stimulates the hypothalamus to produce thirst and eventually raises blood pressure. This mechanism is also caused by factors such as renal artery stenosis and sympathetic excitation. 3, the kidney itself can also cause blood pressure, such as renal disease, renal artery stenosis and so on, the previous has been said, here is not repeated. Our clinical application of sartans and drugs can target the renin-angiotensin-aldosterone system for intervention and regulation, which can effectively reduce blood pressure. The kidneys are one of the target organs of hypertension. Long-term hypertension can lead to an increase in serum creatinine, a decrease in glomerular filtration rate (eGFR) and/or an increase in urinary albumin excretion (UAE). This leads to decreased renal function and microalbuminuria. 2. In conclusion, hypertension and the kidney are mutually influential and causal. Some factors of the kidney can lead to an increase in blood pressure, and an increase in blood pressure for a long time can cause kidney damage or aggravate the original kidney disease. 3, we must remember to observe the changes in kidney function and urinary routine when conducting the examination and treatment of hypertension. Good control of blood pressure is not only good for our cardiovascular and cerebrovascular, but also a kind of protection for the kidneys.