Leukemia can return to normal after a gene mutation. Complete remission of leukemia is possible after aggressive chemotherapy, when there are no primitive cells in the peripheral blood and no extramedullary leukemia. Bone marrow hematopoiesis is restored in all three lineages, with less than 5% primitive cells, negative immune residuals, and cure is achieved by bone marrow hematopoietic stem cell transplantation. At this time, there may be some original mutations or fusion genes of abnormal genes, such as TP53, RUNX1, etc. will be transformed to negative, suggesting a better curative effect. Currently, hematopoietic stem cell transplantation is the only method that can cure leukemia at its root. After the patient is treated with systemic irradiation, chemotherapy and immunosuppression (fludarabine, leucovorin), normal donor or autologous hematopoietic cells are injected into the patient’s body, replacing the abnormal mutated cells, and re-establishing the normal hematopoietic and immune functions. Leukemia gene mutation can be restored to normal, and the probability is high, so we should keep optimistic mood, actively treat the disease under the guidance of physicians, so that the condition can be effectively controlled, prolonging the survival period, and if appropriate, bone marrow transplantation can be carried out, to achieve the possibility of curing the disease.