Todd’s palsy: Generally, people with epilepsy do not have significant changes in limb function after a seizure, but there are some people with partial motor epilepsy who have inactivity of a twitching limb after a seizure, which lasts for a few minutes to a few hours and then returns to normal. We call this temporary paralysis due to seizure after seizure Todd paralysis, also known as Todd palsy. When a patient with epilepsy develops Todd’s palsy, it often suggests that the patient has organic lesions in the brain, and further examination must be done to clarify the cause. How is this symptom diagnosed? Todd’s palsy is a neurological abnormality that occurs in people with epilepsy, i.e., it is a transient paralysis that occurs in epileptic episodes. The paralysis can be localized or generalized, but usually occurs on only one side of the body. It occurs most commonly after a generalized tonic clonic seizure (grand mal) and may last for several hours or occasionally for several days after the seizure has passed. The most notable significance of the condition is the differential diagnosis with stroke. In the acute phase, certain strokes can trigger a limited seizure. And if Todd’s paralysis occurs in such a context, the patient’s neurological condition is often overestimated, thus leading to medical measures such as thrombolytic therapy errors. For such reasons, thrombolytic therapy is generally recognized as a relative contraindication for seizures presenting in the acute phase of a stroke, especially if evidence of cerebrovascular infarction is still lacking prior to vascular imaging. Thrombolytic therapy is contraindicated in cases where the diagnosis is not clear. It is recommended to use antiepileptic, anticoagulation, vasodilatation, brain cell nutrition, free radical scavenging, acupuncture and other measures, and at the same time, to do further examination as soon as possible, for example, diffusion-weighted imaging in CT and MRI is valuable for the diagnosis of cerebral ischemic stroke.