The high total bilirubin in newborns is due to the physiological characteristics of the child, as the newborn’s metabolism is weak and the liver function is low in processing bilirubin, so the child has high bilirubin, which means the child will have physiological jaundice. The child is generally in good spirits, eats milk normally, and has the same growth and development as children of the same age. Secondly, it is caused by pathological reasons. If the child has viral hepatitis, such as abnormal liver function due to hepatitis B virus or cytomegalovirus infection, neonatal hemolytic disease due to blood type incompatibility with the mother, or if the child has biliary atresia, this can cause high bilirubin levels in the child, leading to jaundice, or neonatal jaundice. Neonatal jaundice can cause bilirubin encephalopathy if it reaches a certain level, which can damage the child’s brain and should be treated promptly.