There is no such thing as a positive anti-SRP antibody. Positive anti-SRP antibody is mainly seen in polymyositis, which needs further relevant examinations to clarify the diagnosis and then be treated with appropriate medication, and whether it is curable or not depends on the patient’s co-morbidities. 1. Anti-SRP antibodies are anti-Signal Recognition Particle (SRP) antibodies, which are regulatory factors found in the endoplasmic reticulum of cells. Positive anti-SRP antibodies are mainly seen in polymyositis, but can also be seen in other co-morbidities, and the treatment depends on the patient’s co-morbidities. 2. Positive anti-SRP antibody can also be seen in myositis combined with interstitial pneumonia or myositis combined with cancer, etc. It is necessary to further improve the blood sedimentation, other autoantibodies, CRP and other related tests to clarify the diagnosis and then be treated with the appropriate drugs. 3. The treatment of polymyositis is mainly based on drugs, including glucocorticoid such as prednisone, immunosuppressant such as cyclophosphamide, immunoglobulin, etc. Half of the patients with this disease can be taken off the drugs and stabilized for a long period of time after regular treatment, while the prognosis of myositis combined with cancer is generally poorer, and the treatment is relatively difficult. It is recommended that patients with positive anti-SRP antibody should go to the rheumatology and immunology department of regular hospitals and other related departments for further relevant examinations, and follow the doctor’s instructions to standardize the treatment.