The causes of toothache include acute pulpitis, dental caries, periodontitis and other diseases caused by the treatment methods include root canal treatment, drug treatment, surgical treatment, etc., in order to achieve the fastest pain, according to the disease causing toothache targeted treatment. 1. Acute pulpitis: for patients with severe pain, taking pain medication (such as ibuprofen) and antibiotics (such as metronidazole, etc.) or cold compresses and other methods generally have the fastest effect. However, these measures can only temporarily relieve pain, and root canal treatment is required. 2. Dental caries: early non-surgical treatment such as the application of stannous fluoride solution, sodium fluoride glycerin paste. For patients who have already formed caries, surgery can be taken to remove carious lesions, and then fill with suitable materials such as composite resin. For patients with severe pain, anti-inflammatory drugs such as indomethacin and metronidazole can be used to relieve pain. 3. Periodontitis: the pain caused by the first use of the above drugs for pain relief, the effect is not satisfactory can be used antibiotics such as tetracycline, metronidazole, amoxicillin, roxithromycin, etc., in order to eliminate the inflammation around the dental tissues, and at the same time can be combined with the chlorhexidine rinse solution for treatment. Surgical treatment such as periodontal flap surgery can be considered if conservative treatment is ineffective. It is recommended to consult a doctor in time to identify the cause of the toothache and then carry out targeted treatment in order to quickly stop the pain. The use of medication should be in accordance with the doctor’s instructions, do not unauthorized use of drugs.