Copper cyanide, also known clinically as copper oxidase, may be elevated in patients with infectious diseases such as tuberculosis, malignant neoplastic diseases, especially in the hematological system, or hyperthyroidism. Under normal circumstances, it may also be elevated if the patient is taking oral contraceptives or during pregnancy. Patients with nephrotic syndrome or hypoproteinemia due to liver disease may also have elevated copper cyanide. In the hepatobiliary system, patients most commonly develop hepatomegaly, also known as Wilson’s disease. In this type of disease, the patient will have elevated copper cyanide and should be actively monitored for other systemic lesions, extrapyramidal manifestations, early onset of cirrhosis or unexplained ascites, or even liver failure. In such cases, patients diagnosed with hepatomegaly should be actively treated with dietary control and medication in the early stages.