Nasopharyngeal cancer radiotherapy leading to osteonecrosis can be treated by general measures, drug therapy, physical therapy and surgery. 1. General measures: patients need to remove disease-causing factors in time and adjust radiotherapy program for nasopharyngeal cancer patients who take radiotherapy. Meanwhile, it is recommended to use wheelchair and walker to assist activities. 2. Drug treatment: Usually, patients with non-traumatic femoral head necrosis can follow the doctor’s instruction to apply low molecular weight heparin, prostaglandin and other drugs, which can improve osteonecrosis and control the development of the disease to a certain extent. 3. Physiotherapy: Physical measures such as high-frequency electromagnetic field therapy and extracorporeal shock wave can also be considered, which is conducive to the repair of necrotic foci. 4. Surgery: for nasopharyngeal cancer patients with severe osteonecrosis, it is necessary to consider removing the dead bones through surgery and repairing surgery at the same time. To sum up, when osteonecrosis occurs in nasopharyngeal cancer radiotherapy, it is necessary to actively cooperate with doctors for treatment so as not to delay the condition.