Positive syphilis-specific antibodies mean that the person being tested has anti-syphilis antibodies in his or her body, which suggests that he or she may be infected with the spirochete syphilis. A positive syphilis-specific antibody test is a positive serologic test for syphilis antibodies, which means that there are antibodies in the patient’s body due to syphilis infection. However, a positive syphilis-specific antibody test result alone is not a good indicator because it may mean that the patient is being infected with the syphilis spirochete, or that the patient has been infected but has been cured. Although the syphilis-specific antibody test is a way to screen for and confirm syphilis, the diagnosis of syphilis needs to be analyzed in conjunction with the results of other tests, and relying on the test alone cannot determine whether a person has been infected in the past or is currently suffering from the disease. Individuals who receive a positive syphilis-specific antibody result should consult with a medical professional for the next step in the management of the disease.