Body uncomfortable a hard to vomit, the possible causes of peptic ulcer, functional dyspepsia, Meniere’s disease, etc., should be directed to the cause of treatment and choose the appropriate antiemetic drugs. 1. Peptic ulcer: mainly the use of drugs such as omeprazole and other proton pump inhibitors, antiemetic drugs can choose atropine, scopolamine and so on. 2. Functional dyspepsia: prohibit smoking and alcohol restriction, appropriate participation in sports, can use omeprazole, domperidone and other drugs. 3. Ménière’s disease: the choice of drugs benzolamine, ipecac, etc.. Physical discomfort a hard to vomit should be timely medical treatment, in the exclusion of physiological factors leading to vomiting, should be under the guidance of a professional doctor to choose the appropriate treatment drugs, in order to improve the quality of life.