Children with fever in the middle of the night during the day is fine, consider the short duration of antipyretic drugs, high ambient temperature, poor heat dissipation, the influence of the thermoregulatory center. Short duration of antipyretic drugs, most of the antipyretic drugs can continue to work for 4 to 6 hours, such as ibuprofen, oral medication before bedtime, the middle of the night, the decline in efficacy, fever. High ambient temperature, indoors during the day, outdoor activities in a large space, minor symptoms are not easy to cause fever, night sleep indoor air circulation, easy to fever. Poor heat dissipation, wearing less clothes during the day, good heat dissipation, minor fever is not obvious. At night when you sleep with more bedding, poor heat dissipation is also prone to fever. The influence of the thermoregulatory center, the body is stimulated by external excitement during the day, the fever response is temporarily suppressed, the body is in a state of rest at night, the suppressed fever response begins to manifest. Often fever in the middle of the night, actively to the hospital, identify the cause of the disease and then treatment.