Fixed drug rash is the manifestation of a drug rash at a fixed site after certain drugs or similar drugs have been taken orally and imported. The rash can be cured by finding the drug and taking it orally next time, and will not occur as long as the patient is not exposed to similar drugs. It is important to take a strict medical history of these patients and to communicate well with the patient to make it clear. Avoid oral medications later, or diet in the course of life, and patients use medications in the process of stopping itching. If these things are avoided, the drug rash can be eradicated.