There are many kinds of drugs that can be taken for essential hypertension, such as diuretics, beta receptor antagonists, calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin II receptor antagonists. 1. Diuretics: e.g. hydrochlorothiazide. The main adverse reaction is to cause a decrease in blood potassium, so that the blood calcium, blood glucose, uric acid increase, severe renal insufficiency, hepatic encephalopathy, hypokalemia patients, etc. are prohibited. 2. β-receptor antagonists: such as metoprolol, bisoprolol and so on. Common adverse reactions include bradycardia, fatigue, cold limbs, etc. Cardiogenic shock, sick sinus node syndrome, second-degree, third-degree atrioventricular block, symptomatic bradycardia or hypotension patients, etc. are prohibited. 3. Calcium channel blockers: such as nifedipine, amlodipine, etc., the main adverse effects are caused by increased heart rate, facial flushing, headache, ankle edema. Patients allergic to dihydropyridines, patients with severe hypotension, patients with severe aortic stenosis are prohibited. 4. Angiotensin converting enzyme inhibitors: such as captopril, enalapril, etc., the main adverse effects are irritating dry cough and angioedema. Angioneurotic edema history, renal artery stenosis, patients with primary liver disease, pregnant women, etc. are prohibited. 5. Angiotensin II receptor antagonist: such as chlorosartan, valsartan and so on. Hyperkalemia, pregnant and lactating women, bilateral renal artery stenosis is prohibited. If you need to treat primary hypertension, you should go to a regular hospital, standardized treatment under the guidance of a professional doctor, not blindly self-medication, so as not to cause adverse reactions.