The tendency to get angry and lash out is more common in schizophrenia and mania in clinical practice. Patients with schizophrenia, often under the domination of hallucinations or delusions, perform emotional expressions, especially under the domination of delusions of victimization and commentary hallucinations, patients tend to talk to themselves, appear aggressive towards others, get angry and lash out, and become uncontrollable over minor matters. Therefore, when patients exhibit symptoms that meet the diagnostic criteria of schizophrenia, they need systematic antipsychotic medication, such as the application of olanzapine, quetiapine, risperidone and other treatments. In addition, patients with mania can also appear to be irritable and angry, especially when the performance of high emotion is not typical, they are often mainly irritable, and they can easily get angry because of small trifles, and in serious cases, they can be impulsive and appear to be angry and irritable, so at this time, they should apply emotion stabilizers or antipsychotic drugs for systemic treatment, which can achieve good therapeutic effects.