Most cancers rarely survive 20 years without surgery. Cancer is a malignant tumor that grows very rapidly and is prone to metastasis, leading to death even within a short period of time. Early-stage cancers have the potential for long-term survival through surgical treatment and other options; if not treated aggressively, they can quickly progress to advanced stages, which can lead to multi-organ metastasis and even death. Once advanced cancer develops, the opportunity for surgery is often lost, and although the disease can be controlled by chemotherapy, targeted therapy, radiotherapy and other methods, the 20-year survival rate of patients is also very low. Among them, some cancers of the blood system such as lymphoma and leukemia can be treated without surgery, and chemotherapy and radiotherapy are the mainstay, and a few patients with better treatment results can survive for up to 20 years, such as some inert lymphomas. It is recommended to actively consult doctors for standardized treatment, which can help improve the prognosis and prolong the survival period.