The causes of calf soreness and ankle pain may be fatigue, lower extremity venous thrombosis, soft tissue injury, lumbar spine disease and so on. 1. Exhaustion: the accumulation of lactic acid in the calf muscles due to prolonged standing, walking, running, etc. leads to the symptoms of calf soreness and ankle pain. 2. Lower extremity venous thrombosis: there will be a lack of blood supply to the lower extremities, resulting in symptoms of calf soreness and ankle pain, and there will also be an increase in the skin temperature of the lower extremities as well as a change in the color of the skin. 3. Soft tissue injuries: soft tissue injuries such as muscle and ligament injuries in the lower limbs due to strenuous exercise will also cause symptoms of calf soreness and ankle pain. 4. Lumbar spine disease: lumbar disc herniation, lumbar spinal stenosis or lumbar spine slippage, there may be nerve compression symptoms, resulting in calf soreness and swelling ankle pain symptoms, but also can be accompanied by lower limb numbness, weakness, and lumbago symptoms. There may also be other causes of calf soreness and ankle pain, it is recommended to go to the hospital in time to find out the cause of the disease and then targeted treatment.