Pyriformis syndrome can be treated with oral medications such as non-steroidal anti-inflammatory analgesics, nutritive nerve medications, decongestants, muscle spasm relievers, or hormones. Piriformis syndrome requires drug treatment for different conditions due to different pathological changes such as aseptic inflammatory reaction of the localized lesion, muscle spasm, edema, and entrapment of nerves. 1. Non-steroidal anti-inflammatory and analgesic drugs: non-steroidal anti-inflammatory and analgesic drugs are commonly used in the treatment of pyriformis syndrome, which can alleviate the local inflammatory stimulus and thus reduce pain. Such as acetaminophen, diclofenac sodium and so on. 2. Nutritional nerve drugs: generally long-term pyriformis syndrome will affect the sciatic nerve, resulting in nerve damage, so you need to take oral methylcobalamin and other nutritional damage to the nerve. 3. Decongestive drugs: such as oral hepatic saponin sodium tablets can relieve the pain symptoms of pyriformis syndrome edema, usually used in combination with anti-inflammatory and analgesic drugs. 4. Relief of muscle spasm drugs: such as oral ethylprednisolone hydrochloride tablets to relieve pain caused by muscle spasm, need to be used according to the specific circumstances of the pyriformis syndrome, not all pyriformis syndrome have to be taken orally. 5. Hormones: such as dexamethasone tablets, etc., can have a relieving effect on acute or chronic pyriformis syndrome caused by severe pain, due to the adverse effects of hormone drugs, generally not as a routine use of drugs. When taking the above medications orally for the treatment of pyriformis syndrome, you need to take them under the guidance of your doctor.