After receiving the 13-valent pneumonia vaccine, children may cry intermittently for about 3 days, in which the crying may be more severe at night than during the day, and if the crying does not subside or if the adverse reaction worsens significantly, the child should consult a doctor promptly. After receiving 13-valent pneumonia vaccine, infants and children usually cry on the second day, which may be due to some pain at the vaccination site after vaccination, which triggers infants and children’s discomfort and leads to crying. It may also be due to some systemic adverse reactions of the body after vaccination, such as fever, irritability, irritability, poor mental health, loss of appetite, etc., which may also aggravate the crying of infants and young children. When the child is crying, parents can effectively relieve the child’s crying state by soothing him or her. General vaccination after the adverse reactions will be reduced or subside within 3 days, when the child crying phenomenon will also be eased, if the child continues to cry without improvement or adverse reactions significantly aggravated should seek medical attention in a timely manner.