The most common disease with mucus in the stool is ulcerative colitis or Crohn’s disease. Ulcerative colitis is most typically characterized by mucus without pus and blood or mucopurulent stools, a condition that is often due to increased secretion from colonic ulcers, resulting in the discharge of mucus. Similar manifestations can also be seen in tuberculosis, especially ileal intestinal tuberculosis, but intestinal tuberculosis can manifest as tuberculosis toxicity with fever, afternoon hypothermia, or night sweats. For poor digestion, gastrointestinal dysfunction or irregular diet, eating more greasy and fried food, a similar situation with mucus in the stool can also occur. Therefore, it is necessary to improve the routine stool examination and, if necessary, the colonoscopy to further clarify the diagnosis.