The common causes of uncomfortable knee swelling include septic knee arthritis, osteoarthritis of the knee, gout, etc. Corresponding treatments should be carried out according to the causes, and the commonly used treatments include general treatment, physical therapy, medication and surgery. 1. Septic knee osteoarthritis: fix the knee joint in functional position with plaster cast or skin traction, use antibiotics such as penicillin and clindamycin at early stage in sufficient quantity systemically, and also carry out puncture irrigation or continuous irrigation of the joint cavity, and arthrocentesis and drainage is feasible in serious cases. 2. Osteoarthritis of the knee: Avoid large activities and reduce weight bearing on the joints. Massage, acupuncture, massage can reduce symptoms and relieve joint stiffness. Commonly used drugs include non-steroidal analgesic and anti-inflammatory drugs such as diclofenac and flurbiprofen, etc. Glucocorticosteroids such as budesonide can also be injected into the joint cavity. In severe cases, joint fusion can be performed. 3. Gout: Drink a lot of water, avoid intake of high-purine foods such as animal offal, fish, shrimp, etc., and prohibit smoking and alcohol. Commonly used drugs include non-steroidal analgesic and anti-inflammatory drugs such as indomethacin, etc., uric acid-lowering drugs such as allopurinol, etc., colchicine is the traditional therapeutic drug, accompanied by renal insufficiency, can be used glucocorticosteroids such as prednisone. Surgery can be used if necessary. There may be other reasons for the uncomfortable swelling of the knee, such as chronic strain. It is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and standardize the treatment under the guidance of the doctor. The above drugs should be used under the guidance of a doctor, avoid self-medication.