In actual clinical practice, the antihypertensive drugs with relatively few side effects are first-line antihypertensive drugs, of which the first-line antihypertensive drugs mainly refer to the five major classes of antihypertensive drugs, including diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists and calcium channel blockers. These five categories of antihypertensive drugs are the least side effects and the most effective among all types of antihypertensive drugs, and patients are advised to routinely choose these five categories of antihypertensive drugs. Unless the patient takes these five categories of antihypertensive drugs in combination, or use one of them can not tolerate, or blood pressure can not reach the standard, you can consider the application of other categories of antihypertensive drugs. The representative drugs of diuretics are hydrochlorothiazide, the representative drugs of calcium channel blockers are felodipine and nifedipine, the representative drugs of angiotensin II receptor antagonists are temisartan, the representative drugs of angiotensin-converting enzyme inhibitors are perindopril, the representative drugs of beta-blockers are bisoprolol and metoprolol, etc.