Lupus, known as systemic lupus erythematosus, is an autoimmune disease in which pathogenic autoantibodies and immune complexes form and mediate organ and tissue damage, often with manifestations of multisystem involvement, which can threaten the health of patients and even shorten their life span. SLE can cause varying degrees of damage to several organs of the body and can destroy the physiological functions of multiple organs and systems, such as the kidneys, digestion and blood, and was once considered a disease with a high mortality rate. In the 1950s, the 4-year survival rate of patients with SLE was only 50%. However, since glucocorticoids and immunosuppressants have been used in the treatment of SLE, the situation has improved dramatically. The 10-year survival rate of SLE patients has now reached 90%, and the 15-year survival rate can also reach 80%. With comprehensive and standardized treatment, most patients can work and live like normal people. However, it should be pointed out that the clinical manifestations of SLE are often complex and varied, and the severity of the disease varies from patient to patient, and the patient’s disease urgency, responsiveness to drugs, living habits and mentality all have great influence on the prognosis of patients. It is extremely important for patients with lupus to maintain a good attitude and adhere to systematic and standardized treatment. Therefore, for most patients with SLE, after early diagnosis and systematic and standardized treatment, the prognosis is better and the average survival period is greatly extended.