The cause of high creatine kinase isoenzyme in children is mainly due to damage to the myocardium of children. In children with viral or bacterial infections, myocardial damage may occur, especially in children with enterovirus infections, and myocardial enzymes may be generally elevated after myocardial damage. Creatine kinase isoenzyme is a specific indicator of myocardial enzymes in children, which can effectively reflect myocardial damage. Therefore, high creatine kinase isoenzyme in children is mostly due to myocarditis. After the change of ECG, children should be relieved with myocardial nutrients, such as oral solution of Rui-angi for children. When the heart muscle is protected, the creatine kinase isoenzyme will naturally return to normal.