The wall of the gallbladder is not smooth, which is a description of the gallbladder condition in the imaging examination. The corresponding change suggests that the wall of the gallbladder is abnormal, and it needs to be combined with the clinical symptoms and laboratory tests to make a comprehensive judgment, and the common causes include congenital development of the gallbladder, cholecystitis, diverticulum of the gallbladder, and postoperative period of the gallbladder. 1. Congenital development of gallbladder: some gallbladder wall will have folds due to abnormal congenital development, which will show corresponding changes and is caused by congenital development. 2. Cholecystitis: localized gallbladder wall thickening, edema and rough edges in cholecystitis will show corresponding changes. 3. Gallbladder diverticulum: the local gallbladder wall is weak and protrudes outward, there will be corresponding changes. 4. Post-operative gallbladder: some people have had biliary lithotripsy surgery, and there will be corresponding conditions. The gallbladder wall is not smooth, accompanied by obvious symptoms of abdominal pain, you need to consult a doctor in time to observe, under the guidance of the clinician standardized treatment.