After infection with H. pylori, 80% to 90% of patients can be completely cured with systematic and comprehensive treatment. For initial H. pylori infection, triple therapy can be used, with a common regimen of one proton pump inhibitor plus two antibiotics. The proton pump inhibitor can choose one of omeprazole, pantoprazole, etc.; antibiotics mainly include amoxicillin, levofloxacin, clarithromycin and metronidazole. If triple therapy treatment fails, quadruple therapy can be used for treatment. That is, one proton pump inhibitor, one bismuth agent and two antibiotics, which is to add one bismuth agent, such as bismuth potassium citrate or colloidal bismuth pectin, on the basis of triple therapy. The above medications should be used under the guidance of a medical professional. After infected with Helicobacter pylori, it is recommended to consult a doctor in time, and most of them can be cured with early, standardized and sufficient treatment under the guidance of professional physicians.