You should not take aspirin after drinking for the following reasons: First, because aspirin is a common, adverse drug for gastric damage, and alcohol can also cause damage to the gastric mucosa, their joint use can significantly increase the risk of gastric damage and may even induce gastrointestinal bleeding in severe cases. Secondly, both aspirin and alcohol can have adverse effects on the liver, and the use of aspirin after drinking alcohol increases the risk of liver damage. Finally, alcohol is absorbed into the body after drinking, and the decomposition of alcohol requires an ethanol dehydrogenase enzyme, but aspirin can inhibit the activity of this enzyme, slowing down the metabolism of alcohol and causing the accumulation of alcohol in the body, while drinking and taking aspirin can aggravate the state of intoxication and make it easier for alcohol poisoning to occur.