Acne at the corners of the mouth can be treated by lifestyle adjustment, topical vitamin A acid, oral doxycycline, loratadine, topical acyclovir ointment and other medications. Common diseases include acne, perioral dermatitis, allergies, herpes simplex and so on. 1. Healthy people experience acne at the corners of the mouth after staying up late and eating a spicy and stimulating diet, which is often relieved by improving lifestyle and eating a light diet, and is generally a self-limiting disease. 2. Acne: chronic inflammation of the sebaceous glands of the hair follicles, which can be treated with topical retinoic acid and benzoyl peroxide, and glucocorticosteroids such as prednisone can also be used for polymerized acne or eruptive acne. 3. Perioral dermatitis: there may be rash, itching and herpes, which can be treated with topical erythromycin and metronidazole ointment, or oral tetracycline. 4. Allergy: contact with pollen, seafood and other substances can be due to allergies, acne, often accompanied by itching, the need to terminate contact in a timely manner, oral loratadine and other drugs. 5. Herpes simplex: caused by herpes simplex virus, the rash can be pimples, blisters, accompanied by itching or pain, can be used externally with antiviral drugs such as acyclovir ointment. When the corners of the mouth acne, there may be other reasons, should be timely consultation in the hospital, clear causes under the guidance of a professional doctor symptomatic treatment, do not blindly deal with their own. All of the above drugs should be used under the guidance of a doctor.