Ankle depression edema is a phenomenon in which the skin exhibits pallor, swelling, shallow wrinkles, low local temperature, and poor elasticity when excessive body fluid accumulates in the subcutaneous tissue spaces of the ankle. Patients may experience indentation after pressing the ankle skin with their fingers, and this indentation may last for several seconds to a minute before subsiding after the fingers are released. This is due to the fact that there is more free water in the subcutaneous interstitial space when the depressed edema is present, and the local pressure increases due to the compression, causing the free water to move to the lower pressure area. Ankle sunken edema may be caused by prolonged standing or sitting, drug stimulation, female pregnancy, kidney disease and many other reasons: 1, prolonged standing or sitting: prolonged standing or sitting leads to poor blood circulation in the lower extremities, which increases fluid in the lower extremity tissues, and then sunken edema appears in the ankle, and patients are advised to avoid prolonged standing or sitting and to relax with appropriate activities; 2, drug stimulation: including anti hypertensive drugs, hypoglycemic drugs, anti-anxiety drugs, etc. act on the body to cause edema, for example, anti-hypertensive drugs, such as calcium antagonists, can easily lead to lower limb edema. Patients are recommended to adjust the dose or change the drugs under the guidance of doctors, which is beneficial to alleviate the symptoms of edema; 3. Female pregnancy: during pregnancy, the pressure in the pelvis increases and the venous return of the lower limbs is affected. In addition, changes in hormone levels in women’s bodies during pregnancy play a role in water and sodium retention, which can cause the phenomenon of sunken edema in the ankle. In this case, you can exercise appropriately to promote blood circulation and accelerate kidney filtration can promote fluid discharge. You can also properly pad the lower limbs to reduce edema; 4, kidney disease: kidney disease leads to large amounts of proteinuria, hypoalbuminemia, excess fluid in the body can not be discharged out of the body, retained in the subcutaneous tissue, can appear ankle sunken edema, it is recommended that patients actively treat kidney disease to relieve edema symptoms; 5, other: such as heart disease (heart failure, heart valve lesions, etc.), endocrine disease, malnutrition, etc., also can lead to the occurrence of ankle edema. Patients can go to the hospital for echocardiography and chest X-ray examination to clarify the diagnosis. Patients with sunken edema in the ankle should go to the hospital promptly for examination to clarify the cause before symptomatic treatment. Some patients can also use diuretics to excrete excess water and thus reduce symptoms. Patients are also advised to elevate the ankle normally to help relieve the symptoms.