Screening for high risk of Down syndrome requires further amniocentesis and prompt induction of labor if the diagnosis of trisomy 21-trisomy is confirmed. Screening for Down’s syndrome is usually performed at 15-20 weeks of gestation with Down’s syndrome screening or at 12-22+6 weeks of gestation with non-invasive DNA. If the test reveals a high risk of trisomy 21, it indicates that the fetus is at a higher risk of Down’s syndrome, and further amniocentesis is needed to make a prenatal diagnosis. If 21-trisomy is confirmed, labor needs to be induced promptly. If not, the pregnancy can continue. Giving birth to a Down’s syndrome baby is a heavy burden for the child and the family. Pregnant women should pay attention to the prenatal checkups during pregnancy, and if abnormalities are found, they should be dealt with in a timely manner. During pregnancy, you should also pay attention to strengthen nutrition, avoid exposure to harmful substances, to ensure the healthy growth of the fetus.