Bullous psoriasis generally refers to psoriasis, also known as psoriasis, middle-aged and old women with severe psoriasis can be treated by daily care, medication and physical therapy. 1. daily care: psoriasis is related to immune system, heredity, environment and other factors, daily to keep local skin hygiene, make the skin get sufficiently clean and moist, avoid skin dryness, wear loose and breathable or easy to absorb the moisture of the clothing, reduce the friction and stimulation of the skin, and keep regular work and rest. 2. Medication: For severe psoriasis in middle-aged and old women, according to their actual situation, under the advice and guidance of doctors, they can apply tacrolimus ointment, pimecrolimus cream, carbotenol cream externally, take methotrexate, cyclosporine, Avicenna, or subcutaneous injections of biologics and other medications. 3. Physical therapy: Middle-aged and elderly women with severe psoriasis can be treated with physical therapy such as ultraviolet light therapy according to their actual conditions and under the advice of doctors. Psoriasis may persist and recur, so it should be treated in a reasonable way to actively control the development of the disease and avoid causing more serious damage to the body, and the above medications should be used under the guidance of a doctor.