Itching in the nose in the middle of the night and waking up with itching are most often caused by allergic rhinitis. It is likely that the allergy is caused by exposure to obvious allergens, such as dust mites in the air or in the bedding, while sleeping at night, and is accompanied by sneezing, nasal congestion, and runny nose. At this time, if the symptoms are obvious, you can consider taking oral anti-allergy drugs such as cetirizine hydrochloride or stavastine hydrochloride, and spraying nose drugs such as coleus or endosulfan; at the same time, you can consider washing the nasal cavity with light saline. If there is no light saline, you can also use ordinary warm water to wash to relieve the symptoms.