Ankylosing spondylitis usually does not cause skin symptoms, but mainly manifests as pain, hypermobility, deformity and other symptoms in the diseased areas such as lumbar back and joints, as well as extra-articular manifestations. 1. Lumbar back manifestations: mainly manifested as lower back pain, can also be manifested as hip, groin to the lower limbs of the radiation of pain, mostly in rest, sedentary aggravated, usually after the activities can be reduced, late patients can also be accompanied by lumbar spine in all directions of restricted movement, hunchback deformity and other discomforts. 2. Joint manifestations: mainly for the lower limb large joint pain, such as hip, knee, ankle, etc., can be recurrent, hip joints can be affected by swaying gait. 3. Extra-articular manifestations: some patients may also develop uveitis, dilatation of the root of the ascending aorta, aortic valve lesions, progressive fibrosis of the upper lobe of the lungs, renal function abnormalities, neurological lesions and so on. Symptoms such as blurred vision, photophobia, tearing, palpitations (rapid heartbeat, often accompanied by panic), shortness of breath, cough, dyspnea, lower limb numbness, urinary and defecation disorders. 4. Others: osteoporosis, paralysis, pressure pain at the lesion site, etc. Patients with the above symptoms, suspected the existence of ankylosing spondylitis, it is recommended to consult a doctor in a timely manner, under the guidance of a doctor to clarify the diagnosis of the disease, and to carry out the appropriate treatment, do not blindly judge, so as to avoid delays in the condition.