Pimples on the forehead between the eyebrows are a manifestation of acne and can be treated with topical medications, oral medications, physical therapy or surgery. 1. Topical medication: The treatment of acne is related to the extent of the disease. If the symptoms are mild, topical medication is the main treatment. Antibacterial drugs, such as fusidic acid, clarithromycin and benzoyl peroxide, which can kill Propionibacterium acnes and have anti-inflammatory effects, can be given under doctor’s supervision. Topical tazarotene gel and adapalene gel can improve the keratinization of sebaceous gland ducts and dissolve acne. 2. Oral medications: Oral medications include doxycycline and minocycline, which can fight inflammation and kill Propionibacterium acnes. Retinoids, such as isotretinoin, can dissolve acne, fight inflammation, and improve sebaceous duct keratinization. Acne vulgaris, inflammatory reaction is more serious, can be given short-term oral glucocorticoids, such as prednisone, dexamethasone treatment. 3. Physical therapy: Pharmacological treatment can also be combined with photodynamic therapy, which aims to inhibit the secretion of sebaceous glands, kill Propionibacterium acnes, and reduce acne scars. 4. Surgery: Acne that has formed cysts can be treated with surgery if necessary, such as cyst incision and drainage, ionized cyst opening, and acne vulgaris removal. Acne is treated in different ways depending on the degree of acne. It is recommended to go to the dermatology department of the hospital and choose the appropriate way of treatment with the doctor’s advice. Medications need to be used as prescribed by the doctor.