In clinical practice, the common side effects of tirilizumab generally include fever, malaise, cough, itchy skin, etc. In severe cases, some patients may develop rash, hypothyroidism, hepatitis, myocarditis and other symptoms. The most common adverse reactions to tirilizumab are fever, hypothyroidism, pruritus, upper respiratory tract infection, rash, decreased neutrophil count, cough, fatigue, and elevated blood bilirubin. In addition, grade 3 and higher adverse reactions may occur including pulmonary inflammation, weight gain, severe skin reactions and hypertension. Immune-related adverse events may occur, primarily including pneumonia, diarrhea and colitis, hepatitis, endocrine disorders, and adverse skin reactions, in addition nephritis, pancreatitis, and myocarditis along with other immune-related events have occasionally occurred. In addition, when using the drug, according to the patient’s physical ability and physical condition of different patients, the side effects of patients also differ, when the symptoms are more serious, it is recommended to go to the hospital in a timely manner for examination and treatment to avoid aggravation of the condition.