Tonic Jiale usually refers to estradiol valerate tablets, after taking it, the onset of menstruation usually occurs about 3~7 days after stopping the medication, and the time of the onset of menstruation may vary due to the different physique of individuals. Estradiol valerate tablets are clinically used in postmenopausal menopausal symptoms or treatment of estrogen deficiency, usually after taking a period of time, stop taking the drug for about 3 to 7 days after the onset of menstruation, if the time is too long and still do not have menstruation, it is recommended to go to the hospital for a detailed examination in a timely manner, and under the guidance of the doctor to be targeted treatment. Estradiol valerate tablets need to be taken under the guidance of a doctor to use, do not self-medication, in order to avoid adverse reactions.