Chronic atrophic gastritis C2 means that patients with chronic gastritis have developed atrophic lesions of gastric mucosa, and this kind of gastric mucosal atrophy belongs to C2 type, which can be operated. Chronic atrophic gastritis is regarded as a precancerous lesion of gastric cancer, and further development can appear intestinalization as well as the emergence of heterotrophic hyperplasia, which will lead to early gastric cancer, therefore, if chronic atrophic gastritis C2 has gastric mucosal heterotrophic hyperplasia, it should be treated with endoscopic mucosal resection in time. After endoscopic mucosal resection, patients should be fasted for 24-48 hours after the operation, supplemented with nutrition through fluids, and after 1-2 days of fasting, they can eat fluids, gradually transitioned to semi-fluids and soft foods, patients should pay attention to bed rest, avoid strenuous exercise, and closely observe the patients’ stool status, and if the patients have any discomfort, they should inform the doctor in time, and standardize the treatment under the guidance of the doctor. Chronic atrophic gastritis C2, should be actively treated under the guidance of the doctor, on time medication, regular review.