Repeated fever in 5-year-old children may be caused by infectious factors such as tuberculosis, or non-sensory factors such as Kawasaki disease and leukemia, and the cause of the fever needs to be addressed in conjunction with antipyretic treatment. Fever is a common symptom in childhood. If a 5-year-old child’s temperature is <38.5℃ without obvious discomfort, physical methods such as applying warm water to the child's forehead and reducing the amount of clothing worn can be used to lower the temperature, and the child should be encouraged to drink more fluids, so that the body temperature of some children can gradually decrease. If the child's body temperature ≥ 38.5 ℃, generally need to use antipyretic drugs such as ibuprofen, acetaminophen and other antipyretic treatment under the guidance of a doctor. At the same time, we need to pay attention to the cause of the treatment, specific analysis is as follows: 1. Tuberculosis: mainly for the afternoon low fever, accompanied by night sweats, fatigue, the treatment of isoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin and other drugs such as anti-tuberculosis treatment as prescribed by the doctor. 2. Kawasaki disease: mainly with fever, eye congestion, strawberry tongue, skin rash, cervical lymph node enlargement and other manifestations, is a self-limiting disease, most of the prognosis is good. If necessary, aspirin, injectable immunoglobulin and other drugs should be used for treatment, and attention should be paid to the observation and follow-up of coronary artery lesions. 3. Leukemia: recurrent fever may also occur. For treatment, vincristine, erythromycin, mendonuclease, prednisone and other drugs should be used as prescribed by the doctor, and bone marrow transplantation should be carried out if necessary. All of the above medications need to be used under the guidance of a doctor, avoid self-medication. There are many other causes of fever in 5-year-olds, so it is recommended to consult a specialist for targeted treatment.