Normal people donate plasma properly to the body without obvious harm, because donating plasma through a special instrument, the human blood in the blood cells are separated out, and then back into the body, the remaining part of the donation is the process of donating plasma. For healthy people, after plasma donation, the body will lose some water as well as albumin, globulin, inorganic ions and various clotting factors in the blood, these solute components can be replenished quickly in a short time, and there is no obvious effect on the body’s function. However, in the case of immunocompromised patients, after plasma donation, the concentration of globulins in the plasma will further decrease, and the immunity will further decline, which will have an obvious effect on the human body. At the same time, in patients with coagulation disorders, the coagulation function of the body will be further impaired after plasma donation, and they will also be prone to bleeding symptoms. People with low immunity and coagulation disorders should not donate blood, but healthy people who donate plasma appropriately have no obvious harmful effects on their bodies.