Liver cancer ablation treatment usually does not have obvious pain. Liver cancer ablation includes physical ablation and chemical ablation, and the most clinically applied one is physical ablation, including Ar-He knife cryoablation, microwave ablation and radiofrequency ablation. Ar-He cryoablation is a kind of cold-heat ablation, which rapidly reduces the temperature of the tumor tissue to below -120℃ and then warms it up rapidly. Microwave ablation and radiofrequency ablation, on the other hand, will warm the tumor tissue to 60 or even more than 100℃ in a few seconds. Whether it is thermal ablation or cold ablation, it can rapidly cause tumor tissue necrosis, and it can kill tumor cells and also have pain-relieving effect. Chemical ablation uses chemotherapeutic drugs and anhydrous ethanol to kill tumor cells, because of the stimulation of drugs there may be some pain, but generally the operation process through the precise imaging guidance technology, so that the drugs are confined to the internal tumor tissue, together with the injection of anesthesia pain medication, and seldom appear intolerable pain.