Parkinson’s disease is a disease of the central nervous system characterized by muscle tremor, rigidity, difficulty in starting motor activities, and loss of postural reflexes that occurs mostly in middle-aged and older people. It is currently referred to as primary Parkinson’s disease (Parkinson’s disease, tremor paralysis) when the cause is unknown. Similar clinical manifestations arising from encephalitis, cerebral atherosclerosis, traumatic brain injury, and poisoning are referred to as secondary Parkinson’s syndrome (symptomatic Parkinson’s syndrome, Parkinson’s syndrome). All Parkinson’s diseases (PD) have the following common features: they have an insidious onset and worsening, tremor is most pronounced at rest; limb stiffness, causing a reduction in movement, and a gradual loss of the ability to work and live normally; altered facial expression, manifested as a mask-like face, unable to express an emotional response; speech is slow, low-pitched, and monotonous; salivation; prone posture of the torso, and it is not easy to maintain the upright posture; grease overflow leading to Skin with seborrheic dermatitis tendency. Recent results of randomized surveys in 15 cities in China have shown that it is not a low incidence area as previously thought, and the results are similar to those reported in other Western countries.The incidence and prevalence of PD increases with age.The age of onset of PD is about 20/100,000 for 0-39 years old, and about 1,100/100,000 for 70-79 years old, and is prevalent in the age of 50-65 years old, with the youthful type being rare. The male-to-female ratio is close to 1 or slightly higher in males than in females. The etiology of PD is currently thought to be related to environmental factors, genetic factors and aging factors, but the molecular pathological mechanisms of the interaction between the three are still not well understood and need further study. PD itself is not a fatal disease and generally does not affect life expectancy; however, if patients do not receive timely and reasonable treatment, it can easily lead to a decline in physical function and even an inability to take care of themselves, and eventually various complications, such as pneumonia, urinary tract infections, and bone fracture, which can seriously affect the quality of life of patients. For primary Parkinson’s disease, taking levodopa has good efficacy, but the efficacy of the drug will gradually decline or side effects will occur. For PD patients who have begun to affect their normal work and life, we recommend surgical treatment. Minimally invasive stereotactic surgery for the treatment of Parkinson’s disease has the advantages of less trauma, faster recovery and obvious effect. Deep microelectrode brain stimulation (DBS) is currently a high-end treatment measure, but it is expensive, and only patients with financial means should consider this treatment.